What are protein interactions?
Protein interactions are the way in which proteins interact with various tissues and proteins within those tissues. Because no proteins are able to act alone, understanding protein-protein interactions can give us insight into a specific gene's function and mechanism of interaction.
Why do we study protein interactions?
Protein interactions are important to understanding how diseased develop and progress over a lifetime. By visualizing the way that proteins interact in a normal, non-disease inducing way, researchers can find differences between that and the disease state. These differences can then be studied in order to create drugs or other types of treatment that target the specific genetic problem.
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Why do we study protein interactions?
We can study protein interactions using a variety of different networks. Homologs and model organisms are often used to study protein interactions because many of the networks are conserved across species. Yeast-two hybrid and mass spectrometry are experimental methods that are used to study protein networks. Yeast-two hybrids are usually used for determining interactions that occur inside the nucleus. However, they have a relatively high rate of false positives and false negatives. Within mass spectrometry, there are a few techniques that can be utilized and should be chosen based on the particular project. Databases, like String can also be used in conjunction with these techniques in order to research function, localization and process of the proteins involved.
MSTN protein interactions
Human protein network
Molecular Function: Transcription Factor Cellular component: Nucleus Biological Process: Skeletal muscle regulation Mouse protein network
Molecular Function: Transcription Factor Cellular component: Nucleus Biological Process: Skeletal muscle regulation Rat protein network
Molecular Function: Transcription Factor Cellular component: Nucleus Biological Process: Skeletal muscle regulation Cow protein network
Molecular Function: Transcription Factor Cellular component: Nucleus Biological Process: Skeletal muscle regulation Dog protein network
Molecular Function: Transcription Factor Cellular component: Nucleus Biological Process: Skeletal muscle regulation |
The above protein interactions are for human, mouse, rat, cow and dog. They are relatively similar considering they interact with other transcription factors as well as regulatory proteins. With these protein interactions, it is important to remember that these are not always complete or accurate in their entirety.