What is gene ontology?
Gene ontology is a way to organize and categorize genes, their proteins and their subsequent functions throughout the body. Researchers use the Gene Ontology Project (GO) in order to compile all of this data regarding genes and their corresponding ontologies. These ontologies include a Cellular Component, Molecular Function and Biological Process.
MSTN Cellular Component
The Cellular Component of any gene is the sub cellular location that genes and it's products are active in. In the instance of MSTN, the cleaved and subsequently activated part of the gene itself works in the nucleus directly with gene expression. TGFB then allows for the transcription and eventual synthesis of myostatin. Myostatin continues to control muscle growth throughout the body.
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MSTN Molecular Function
The molecular function of a gene describes how it interacts with its cellular component. While inside of the nucleus, MSTN works as a transcription factor, specifically a an activator. This simulates transcription and synthesis of a protein called myostatin. Myostatin then works throughout the body in order to control the growth and development of skeletal muscle.
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MSTN Biological Process
The action a gene carries out within the body is the Biological Process of that gene. Within the human body and it's homologs, MSTN is strictly involved in the production of the protein myostatin. Myostatin then transfuses through the membrane in order to reach skeletal muscle throughout the body. Once there is negatively regulates proliferation from myoblasts into committed myoblast, which are precursors to fully mature muscle.
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How can we use gene ontology?
Gene ontology can help us understand how specific genes work in bodies and give us a better idea of how they can cause disease. Knowing this can help scientists and researchers create experiments that are better able to study these diseases. For example, in the case of MSTN, because it manifests mainly in the nucleus, we can focus on that part of the cell and determine other characteristics of the activated part of the MSTN gene.
Figures
http://calendariu.com/o/online-mapping-tools.html
http://hdimagegallery.net/nucleus+function+and+structure
http://www.discoveryandinnovation.com/BIOL202/notes/images/overview.jpg
http://www.easynotecards.com/notecard_set/29785
http://hdimagegallery.net/nucleus+function+and+structure
http://www.discoveryandinnovation.com/BIOL202/notes/images/overview.jpg
http://www.easynotecards.com/notecard_set/29785